The UMD-MEN1 mutations database
Record ID: 864

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1252_1263delp.Asp418_Cys421delHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GACAspdel12aInFIn frame delInF

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Pem,NM,RP,HD,CH 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-TA09-M01R-RelativeFemale45

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
79683585
Giraud, S., Zhang, C. X., Serova-Sinilnikova, O., Wautot, V., Salandre, J., Buisson, N., ? Calender, A. (1998). Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders. American Journal of Human Genetics, 63(2), 455?67. doi:10.1086/301953