The UMD-MEN1 mutations database
Record ID: 826

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1243C>Tp.Arg415XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
CGAArgTGAStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Pem,NM,RP,HD,CH NoYes

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-BI07-S01N-ProbandFemale30

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
510664520
Morelli, A., Falchetti, A., Martineti, V., Becherini, L., Mark, M., Friedman, E., & Brandi, M. L. (2000). MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. European Journal of Endocrinology / European Federation of Endocrine Societies, 142(2), 131?7. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10664520