The UMD-MEN1 mutations database
Record ID: 805

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1174G>Tp.Glu392XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GAGGluTAGStopG->TTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Pem,NM,RP,FA,HD Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-MA18-A20E-RelativeFemale

Phenotypic groupDisease
asymptomaticPlease contact curator

Reference


Reference IDPubMed IDReference
2810534569
Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA. Engelbach M1, Forst T, Hankeln T, Tratzky M, Heerdt S, PfŸtzner A, Kann P, Kunt T, Schneider S, Schmidt ER, Beyer J.