The UMD-MEN1 mutations database
Record ID: 781

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS7+2T>C (c.1049+2T>C)HeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GACAspspl+2Spl.T->CTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,NF,Pem,NM,RP,FA,HD 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Donor
GGAgtgagg
79.7 _
GGAgcgagg
52.9 _ *
-33.7 %

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
04-VI04-D15M-ProbandFemale30

Phenotypic groupDisease
StrongPlease contact curator

Reference


Reference IDPubMed IDReference
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