The UMD-MEN1 mutations database
Record ID: 768

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.914G>Ap.Gly305AspHeterozygousLIKELY CAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GGCGlyGACAspG->ATs

StructureKey Residue (HCD)Pyrimidin doubletCpG
NF,Pem,NM,RP,NMH,FA,HD Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 71 (Probably pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-MA18-M01R-RelativeMale43

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
2610664521
A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism M Honda, T Tsukada, H Tanaka, K Maruyama, K Yamaguchi, T Obara, T Yamaji, and M Ishibashi Eur J Endocrinol 142 138-143, doi: 10.1530/eje.0.1420138