The UMD-MEN1 mutations database
Record ID: 758

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.939T>Gp.Tyr313XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
TATTyrTAGStopT->GTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
NF,NM,RP,FA,HD Yes, coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Rma I
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-ST09-M25R-ProbandFemale39

Phenotypic groupDisease
StrongPlease contact curator

Reference


Reference IDPubMed IDReference
1412652570
Cr*pin, M., Escande, F., Pigny, P., Buisine, M.-P., Calender, A., Porchet, N., & Odou, M.-F. (2003). Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis. Electrophoresis, 24(1-2), 26?33. doi:10.1002/elps.200390023