The UMD-MEN1 mutations database
Record ID: 749

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1045C>Tp.Gln349XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
CAGGlnTAGStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,NF,Pem,NM,RP,FA,HD Yes, coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Rma I
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-AR18-O12I-ProbandMale23

Phenotypic groupDisease
StrongPlease contact curator

Reference


Reference IDPubMed IDReference
1515714081
Klein, R. D., Salih, S., Bessoni, J., & Bale, A. E. (2005). Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory. Genetics in Medicine?: Official Journal of the American College of Medical Genetics, 7(2), 131?8. doi:10.109701.GIM.0000153663.62300.F8