The UMD-MEN1 mutations database
Record ID: 671

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.795G>Ap.Trp265XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
TGGTrpTGAStopG->ATs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm,NM,NMH,FA,HD Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-GU09-D15M-RelativeMale36

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
2410576763
N Hai, N Aoki, A Matsuda, T Mori, and S Kosugi Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1) Eur J Endocrinol 141 475-480, doi: 10.1530/eje.0.1410475