The UMD-MEN1 mutations database
Record ID: 663

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS4-15DelTC (c.784-15DelTC)HeterozygousUV

wt codonwt aamutant codonmutant aamutational eventmutation type
AAGLysspl-15Spl.DelTCTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm,NM,NMH,FA,HD 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Cryptic Acceptor?
tcggctcctagAAGC
19 _
ggctcctagAAGCT
74.1 _ *
74.4 %

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-BO21-L01U-ProbandFemale38

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
2410576763
N Hai, N Aoki, A Matsuda, T Mori, and S Kosugi Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1) Eur J Endocrinol 141 475-480, doi: 10.1530/eje.0.1410475