The UMD-MEN1 mutations database
Record ID: 57

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.623delGp.Gly208AlafsX16HeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GGCGlydel1bFs.Stop at 223Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM 

Other variation(s) reported for this sample: c.618C>A

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
04-BA21-C08R-ProbandFemale35

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
1010634374
Goebel, S. U., Heppner, C., Burns, A. L., Marx, S. J., Spiegel, A. M., Zhuang, Z., ? Serrano, J. (2000). Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas. The Journal of Clinical Endocrinology and Metabolism, 85(1), 116?23. doi:10.1210/jcem.85.1.6260