The UMD-MEN1 mutations database
Record ID: 489

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.466G>Tp.Gly156CysHeterozygousLIKELY CAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GGTGlyTGTCysG->TTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): AlwN I
Lost restriction site(s): Hpa II, Msp I

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 82 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-DA22-A12E-ProbandFemale18

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
3917623761
Clinical Testing for Mutations in the MEN1 Gene in Sweden: A Report on 200 Unrelated Cases Emma Tham, Ulla Grandell, Eva Lindgren, G*ran Toss, Britt Skogseid, and Magnus Nordenskj*ld The Journal of Clinical Endocrinology & Metabolism 2007 92:9, 3389-3395