The UMD-MEN1 mutations database
Record ID: 470

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.574C>Tp.Gln192XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
CAGGlnTAGStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM NoNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Acc I
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-CU09-C08R-ProbandMale39

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
1316563611
J*ger, A. C., Friis-Hansen, L., Hansen, T. V. O., Eskildsen, P. C., S¿lling, K., Knigge, U., ? Nielsen, F. C. (2006). Characteristics of the Danish families with multiple endocrine neoplasia type 1. Molecular and Cellular Endocrinology, 249(1-2), 123?32. doi:10.1016/j.mce.2006.02.008