The UMD-MEN1 mutations database
Record ID: 42

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.495C>Gp.Cys165TrpHeterozygousLIKELY CAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
TGCCysTGGTrpC->GTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM Yes, coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): BstK I, Dsa V, ScrF I
Lost restriction site(s): BstN I, BstN I, EcoR II, EcoR II, PflM I

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 71 (Probably pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
04-OU08-N01D-ProbandFemale

Phenotypic groupDisease
Not availablePlease contact curator

Reference


Reference IDPubMed IDReference
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