The UMD-MEN1 mutations database
Record ID: 402

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.440_442delTCAp.Ile147_Ile147delHeterozygousUV

wt codonwt aamutant codonmutant aamutational eventmutation type
ATCIledel3bInFIn frame delInF

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju, Sm,NM,HD 

Other variation(s) reported for this sample: c.IVS1-20G>A (c.1-20G>A)

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-BE01-G05R-ProbandFemale44

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
209766672
Molecular Biology and Genetics - Articles: Mutation of the MENIN Gene in Sporadic Pancreatic Endocrine Tumors Eric H. Wang, Sam A. Ebrahimi, Allan Y. Wu, Carol Kashefi, Edward Passaro, Jr., and Mark P. Sawicki Cancer Res October 1, 1998 58:4417-4420