The UMD-MEN1 mutations database
Record ID: 204

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1590delAp.Gly531ValfsX28HeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GAAGludel1cFs.Stop at 558Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm3,CH 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
04-BR01-R01P-ProbandMale24

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
199361035
Debelenko, L. V, Brambilla, E., Agarwal, S. K., Swalwell, J. I., Kester, M. B., Lubensky, I. A., ? Emmert-Buck, M. R. (1997). Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Human Molecular Genetics, 6(13), 2285?90. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/9361035