The UMD-MEN1 mutations database
Record ID: 1853

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.IVS5-22DelCT (c.825-22DelCT)HeterozygousUV

wt codonwt aamutant codonmutant aamutational eventmutation type
AGGArgspl-22Spl.DelCTTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Impact on splicing
Splice site type Wild type sequence CV Mutant type sequence CV Variation (%)
Branch Point
gcctgaa
90.1 _
gcgaatt
10.8 _ *
-88 %

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-FE18-I19A-ProbandFemale46

Phenotypic groupDisease
SupportingPlease contact curator

Reference


Reference IDPubMed IDReference
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