The UMD-MEN1 mutations database
Record ID: 1849

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.535G>Ap.Glu179LysHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GAGGluAAGLysG->ATs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 41 (Polymorphism)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-CH01-D10E-RelativeFemale64

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
4011102994
Weinhaeusel, A., Vierhapper, H., Schlegl, R., Wagner, T., Muhr, D., Scheuba, C., Niederle, B. and Haas, O. A. (2000), A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1) . Hum. Mutat., 16: 533. doi: 10.1002/1098-1004(200012)16:6<533::AID-HUMU22>3.0.CO;2-5