The UMD-MEN1 mutations database
Record ID: 1706

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.434G>Tp.Ser145IleHeterozygousLIKELY CAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
AGCSerATCIleG->TTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju, Sm,NM,HD Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): Alu I

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 82 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
02-KA18-M01R-ProbandFemale33

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
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