The UMD-MEN1 mutations database
Record ID: 1700

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1621A>Gp.Thr541AlaHeterozygousPolymorphism

wt codonwt aamutant codonmutant aamutational eventmutation type
ACAThrGCAAlaA->GTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm3,CH NoNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 65 (Probably pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
0-000-000-Proband

Phenotypic groupDisease
Not availablePlease contact curator

Reference


Reference IDPubMed IDReference
3024997771
p.Ala541Thr variant of MEN1 gene: a non deleterious polymorphism or a pathogenic mutation? Nozi*res C1, Zhang CX2, Buffet A3, Dupasquier S4, Vargas-Poussou R3, Guillaud-Bataille M5, Cordier-Bussat M6, Ruszniewski P7, Christin-Maitre S8, Murat A9, Groussin L10, Vezzosi D11, Cardot-Bauters C12, Hervieu V13, Joly MO13, Giraud S2, Odou MF14, Gimenez-Roqueplo AP3, Goudet P15, Borson-Chazot F16, Calender A17; Groupe fran*ais des tumeurs endocrines (GTE). Ann Endocrinol (Paris). 2014 Jul;75(3):133-40. doi: 10.1016/j.ando.2014.05.003. Epub 2014 Jul 2.