The UMD-MEN1 mutations database
Record ID: 135

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1075_1077delGAGp.Glu359delHeterozygousLIKELY CAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GAGGludel3aInFIn frame delInF

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,NF,Pem,NM,RP,FA,HD 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
04-EN15-N09C-RelativeFemale61

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
69463336
Bassett, J. H., Forbes, S. A., Pannett, A. A., Lloyd, S. E., Christie, P. T., Wooding, C., Thakker, R. V. (1998). Characterization of mutations in patients with multiple endocrine neoplasia type 1. American Journal of Human Genetics, 62(2), 232?44. doi:10.1086/301729