The UMD-MEN1 mutations database
Record ID: 1349

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1658delTp.Phe553SerfsX6HeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
TTCPhedel1bFs.Stop at 558Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm3,CH 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-LE10-A07A-RelativeFemale11

Phenotypic groupDisease
asymptomaticPlease contact curator

Reference


Reference IDPubMed IDReference
3311034102
Molecular Biology and Genetics: Screening of the MEN1 Gene and Discovery of Germ-Line and Somatic Mutations in Apparently Sporadic Parathyroid Tumors Shinya Uchino, Shiro Noguchi, Mari Sato, Hiroto Yamashita, Hiroyuki Yamashita, Shin Watanabe, Tsukasa Murakami, Masakatsu Toda, Akira Ohshima, Tetsuhiro Futata, Tsunenori Mizukoshi, Eisuke Koike, Keisuke Takatsu, Kyoichi Terao, Shigeko Wakiya, Miho Nagatomo, and Mitsuo Adachi Cancer Res October 1, 2000 60:5553-5557