The UMD-MEN1 mutations database
Record ID: 1318

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.466G>Cp.Gly156ArgHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
GGTGlyCGTArgG->CTv

StructureKey Residue (HCD)Pyrimidin doubletCpG
Ju,Sm,NMH,HD,NM Yes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): Hpa II, Msp I

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0 - 82 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
01-BO21-A14N-ProbandFemale39

Phenotypic groupDisease
ModeratePlease contact curator

Reference


Reference IDPubMed IDReference
3817766710
O Vierimaa, T M L Ebeling, S Kyt*l*, R Bloigu, E Eloranta, J Salmi, E Korpi-Hy*v*lti, L Niskanen, A Orvola, E Elovaara, A Gynther, T Sane, M V*lim*ki, J Ignatius, J Leisti, and P I Salmela Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype?phenotype correlation Eur J Endocrinol 157 285-294, doi: 10.1530/EJE-07-0195