The UMD-MEN1 mutations database
Record ID: 1258

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1579C>Tp.Arg527XHeterozygousCAUSAL

wt codonwt aamutant codonmutant aamutational eventmutation type
CGAArgTGAStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
Sm3,CH Yes, coding strandYes

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): Bsu36 I
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of DeathGeographic origin
03-KO08-A14G-ProbandFemale

Phenotypic groupDisease
Please contact curator

Reference


Reference IDPubMed IDReference
2715670192
Ellard, S., Hattersley, A. T., Brewer, C. M. and Vaidya, B. (2005), Detection of an MEN1 gene mutation depends on clinical features and supports current referral criteria for diagnostic molecular genetic testing. Clinical Endocrinology, 62: 169?175. doi: 10.1111/j.1365-2265.2005.02190.x