The UMD-FBN1 mutations database
Record ID: 2278

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1954T>Ap.Cys652SerHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
TGTCysAGTSerT->ATv

StructureKey Residue (HCD)Pyrimidin doubletCpG
cb EGF-like #06 Disulfide bonds 639-652 (C6)NoNo

Mutation impact


At the mRNA levelOn restriction map
NANew restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0.830.00 (pathogenous)88 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
FRA01BOU F0535 I0572ProbandMaleNAFRANCE

Phenotypic groupDisease
NAUnknown

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
207-
Boileau C. (personnal communication 2013)