The UMD-FBN1 mutations database
Record ID: 2259

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.7868dupp.His2623GlnfsX18HeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CACHisins1cFs.Stop at 2640

StructureKey Residue (HCD)Pyrimidin doubletCpG
cb EGF-like #42 Ca2+ binding

Mutation impact


At the mRNA levelOn restriction map
Duplication flanked by direct repeatsNew restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
FRA01BOU F0514 I0551ProbandMaleNAFRANCE

Phenotypic groupDisease
NAClassical MFS

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
207-
Boileau C. (personnal communication 2013)