The UMD-FBN1 mutations database
Record ID: 1004

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.3344A>Gp.Asp1115GlyHeterozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
GATAspGGTGlyA->GTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
cb EGF-like #13 Ca2+ bindingYes, non coding strandNo

Mutation impact


At the mRNA levelOn restriction map
NANew restriction site(s): none
Lost restriction site(s): none

Conservation (0-1)SIFT (0-1)UMD-predictor (0-100)
0.830.00 (pathogenous)100 (Pathogenous)

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
GER01BER F0066 I0001ProbandNANAGERMANY

Phenotypic groupDisease
NANA

Clinical data


Symptom
Clinical data will be implemented as soon as possible

Reference


Reference IDPubMed IDReference
129-
Robinson P. (Personnal comunication 2004-2006).