The UMD-CSB mutations database
Record ID: 70

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.229C>Tp.Arg77XHomozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CGAArgTGAStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
 Yes, coding strandYes

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
UVS1KOProbandJAPAN

Phenotypic groupDisease

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
915486090
Horibata K, Iwamoto Y, Kuraoka I, Jaspers NG, Kurimasa A, Oshimura M, Ichihashi M, Tanaka K. Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome. Proc Natl Acad Sci U S A 2004;101(43):15410-5.