The UMD-CSB mutations database
Record ID: 57

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.2203C>Tp.Arg735XHomozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
CGAArgTGAStopC->TTs

StructureKey Residue (HCD)Pyrimidin doubletCpG
 NoYes

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
GM10905ProbandMEXICO

Phenotypic groupDisease

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
710767341
Colella S, Nardo T, Botta E, Lehmann AR, Stefanini M. Identical mutations in the CSB gene associated with either Cockayne syndrome or the DeSanctis-cacchione variant of xeroderma pigmentosum. Hum Mol Genet 2000;9(8):1171-5.