The UMD-CSB mutations database
Record ID: 50

Mutation description


Variation name (cDNA level)Variation name (protein level)Variation statusVariation class
c.1035insTp.Lys345AsnfsX24HomozygousMutation

wt codonwt aamutant codonmutant aamutational eventmutation type
AAALysins1cFs.Stop at 368Fr.

StructureKey Residue (HCD)Pyrimidin doubletCpG
 

Mutation impact


At the mRNA levelOn restriction map
New restriction site(s): none
Lost restriction site(s): none

Patient and sample data


Sample IDPatient statusGenderTransmissionAge of onsetAge of deathGeographic origin
V.7ProbandISRAEL

Phenotypic groupDisease

Clinical data


Symptom

Reference


Reference IDPubMed IDReference
518446857
Falik-Zaccai TC, Laskar M, Kfir N, Nasser W, Slor H, Khayat M. Cockayne syndrome type II in a Druze isolate in Northern Israel in association with an insertion mutation in ERCC6. Am J Med Genet A 2008;146A(11):1423-9.