The UMD-APC mutations database
Mutation c.IVS5+32C>T (c.645+32C>T)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Cryptic Donor?	ACAgcgaag	41.6 _	ACAgtgaag	68.5 _ *	39.2 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	APC	MLH1	MSH2	MSH6	MUTYH
19_16325---16325.001	-	-	-	-	-
19_17507---17507.001	-	-	-	-	-
19_18015---18015.001	-	-	-	-	-
19_19581---19581.001	-	-	-	-	-
19_19668---19668.001	c.3386T>C (p.Leu1129Ser)	-	-	-	-
19_20906---20906.001	-	-	-	-	-
19_20909---20909.001	-	-	-	-	-
19_20972---20972.001	-	-	-	-	-
19_21781---21781-001	c.3602C>A (p.Ser1201X) c.638G>A (p.Arg213Gln) c.3691C>G (p.Leu1231Val) c.7201C>T (p.Leu2401Leu)	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Co-occurrence	APC: c.3602C>A, p.Ser1201X	22/07/13	19
Co-occurrence	APC: c.3927_3931del	19/09/13	19
Allele frequency	Presence of unaffected adult homozygotes	18/09/13	19
Co-occurrence	MSH6: c.1574_1578dup, Leu527Cysfs*5	18/09/13	19

Biological significance	Date	Comment
Neutral	18/09/13	---