The UMD-APC mutations database
Mutation c.IVS10-6A>G (c.1409-6A>G)

Splice site type	Wild type sequence	CV	Mutant type sequence	CV	Variation (%)
Cryptic Acceptor?	TGCCCTTTTTAAATT	53 _	TGCCCTTTTTAGATT	81.9 _ *	35.3 %

     Data for this mutation

Co occurence of MLH1, MSH2, MSH6, MUTYH and APC mutations (Pathogenic mutations, Unclassified variants, Non-pathogenic variation)

Sample ID	APC	MLH1	MSH2	MSH6	MUTYH
19_25083---25083-001	-	-	-	-	-
33_SAT554---10-601	-	-	-	-	-
7_-802ILP0611335E061265	-	-	-	-	-
7_-802ILP0711063E071187	-	-	-	-	-
SO_-802G04527G04527	-	-	-	-	-
SO_-802G04528G04528	-	-	-	-	-

Complementary data about this mutation

Analysis	Result	Date	Origin	PMID/dbSNP
Cosegregation analysis	LOD score: 1,2	22/07/13	7
Ex vivo analysis	Splicing reporter minigene pCas: insertion of 5 nt of intron 10	22/07/13	19

Biological significance	Date	Comment
Causal	22/07/13	---