The UMD-APC mutations database
Variations with a biological significance = Likely neutral

    Request ID: 536957719

Old nomenclature	cDNA Nomenclature	exon	mRNA nomenclature	Protein nomenclature	Functional Domain	Biological significance	Validation by	Validation date	# records
450A>G	c.450A>G	4		p.Lys150Lys		Likely Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2429 10_--------- Likely Neutral - 10 5107 SO_-3868G05398G05398 Likely Neutral - 71
457A>C	c.457A>C	4		p.Lys153Gln		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3108 33_PSL2181---08--1948 Likely Neutral - 33
638G>A	c.638G>A	5		p.Arg213Gln		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2753 19_21781---21781-001 Likely Neutral - 19
2099A>C	c.2099A>C	15		p.Asp700Ala	ASEF binding domain ARM6	Likely Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2875 19_12394---12394.010 Likely Neutral - 19 2876 19_12394---12394.003 Likely Neutral - 19
3102G>A	c.3102G>A	15		p.Glu1034Glu	Beta-catenin binding domain 1	Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3171 33_PSL2250---09-0080 Likely Neutral - 33
3173A>G	c.3173A>G	15		p.Asp1058Gly		Likely Neutral	unvalidated	00/00/00	6
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5803 33_PSL1080---07-512 Likely Neutral - 33 5822 33_PSL 1080---07-512 Likely Neutral - 33 2877 19_14572---14572.001 Likely Neutral - 19 3410 37_P11.01217273118435 Likely Neutral - 37 3411 37_P11.01217272118434 Likely Neutral - 37 3412 37_P11.01215367110428 Likely Neutral - 37
3249T>G	c.3249T>G	15		p.Asp1083Glu		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2553 10_--------- Likely Neutral - 10
3425A>C	c.3425A>C	15		p.Asn1142Thr	Beta-catenin binding domain 2	Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2430 10_APC-081---923P Likely Neutral - 10
3471G>A	c.3471G>A	15		p.Glu1157Glu	Beta-catenin binding domain 3	Likely Neutral	unvalidated	00/00/00	5
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2863 19_7580---7580.001 Likely Neutral - 19 2864 19_7580---7580.001 Likely Neutral - 19 3172 33_SAT539---10-273, Likely Neutral - 33 3173 33_PSL1067---07-478, Likely Neutral - 33 3174 33_SAT581---10-1019 Likely Neutral - 33
3511C>T	c.3511C>T	15		p.Arg1171Cys		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2699 10_APC-088---1003P Likely Neutral - 10
3691C>G	c.3691C>G	15		p.Leu1231Val		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2878 19_21781---21781-001 Likely Neutral - 19
3732A>G	c.3732A>G	15		p.Gln1244Gln		Likely Neutral	unvalidated	00/00/00	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5309 SO_-4761G07149G07149 Likely Neutral - 71 2760 19_19208---19208.001 Likely Neutral - 19 3107 33_SAT203---09-1172 Likely Neutral - 33
3739G>A	c.3739G>A	15		p.Ala1247Thr		Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2731 19_18980---18980-001 Likely Neutral - 19
4057G>C	c.4057G>C	15		p.Glu1353Gln		Likely Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2752 19_717---717.001 Likely Neutral - 19 5026 SO_-358G04923G04923 Likely Neutral - 71
4919G>A	c.4919G>A	15		p.Arg1640Gln		Likely Neutral	unvalidated	00/00/00	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5801 19_24250---24250.001 Likely Neutral - 19 2761 19_21206---21206-001 Likely Neutral - 19 2762 19_21206---21206-002 Likely Neutral - 19
5208A>G	c.5208A>G	15		p.Lys1736Lys	Axin binding domain 2	Likely Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3100 33_SAT509---09-1693 Likely Neutral - 33
7201C>T	c.7201C>T	15		p.Leu2401Leu	Microtubule binding domain (ba	Likely Neutral	unvalidated	00/00/00	4
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3068 19_21384---21384-001 Likely Neutral - 19 3069 19_21484---21484-001 Likely Neutral - 19 3070 19_21529---21529-001 Likely Neutral - 19 3071 19_21781---21781-001 Likely Neutral - 19
8068G>A	c.8068G>A	15		p.Ala2690Thr	EB1 & hDLG binding domain (C-t	Likely Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3249 33_SAT379---08-168 Likely Neutral - 33 3510 37_P08.01-E6738--- Likely Neutral - 37