The UMD-APC mutations database
Variations with a biological significance = Neutral

    Request ID: 536715139

Old nomenclature	cDNA Nomenclature	exon	mRNA nomenclature	Protein nomenclature	Functional Domain	Biological significance	Validation by	Validation date	# records
705A>G	c.705A>G	6		p.Leu235Leu		Neutral	unvalidated	00/00/00	6
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5765 37_P13.3624419147877 Neutral - 37 3072 19_10911---10911.001 Neutral - 19 3073 19_14990---14990.001 Neutral - 19 3074 19_17707---17707.001 Neutral - 19 3248 33_PSL1916---08-1289 Neutral - 33 3509 37_P10.02811764103699 Neutral - 37
1121G>A	c.1121G>A	9		p.Arg374Gln		Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2756 19_4821---4821.002 Neutral - 19 2757 19_4821---4821.003 Neutral - 19
1695A>G	c.1695A>G	13		p.Glu565Glu	ASEF binding domain ARM3	Neutral	unvalidated	00/00/00	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3075 19_19208---19208.001 Neutral - 19 3076 19_19208---19208.001 Neutral - 19 3250 33_SAT203---09-1172 Neutral - 33
1959G>A	c.1959G>A	14-15		p.Arg653Arg	ASEF binding domain ARM5	Neutral	unvalidated	00/00/00	29
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2142 4_8061---8061 Neutral - 4 2432 10_APC-034---300P Neutral - 10 2732 19_9040---9040.001 Neutral - 19 2733 19_9040---9040.002 Neutral - 19 2734 19_9040---9040.003 Neutral - 19 2735 19_9040---9040.004 Neutral - 19 2736 19_19207---19207.001 Neutral - 19 2737 19_11604---11604.001 Neutral - 19 3083 20_2437-27---9775 Neutral - 20 3259 37_P03.092000--- Neutral - 37 3260 37_P11.08-E14845--- Neutral - 37 3261 37_P00.061037--- Neutral - 37 3262 37_P00.06699--- Neutral - 37 3263 37_P01.061039--- Neutral - 37 3264 37_P00.061199296225/92173 Neutral - 37 3751 SO_-50121302130 Neutral - 71 4143 SO_-1702G00111G00111 Neutral - 71 4165 SO_-1728G00204G00204 Neutral - 71 4250 SO_-1289G00581G00581 Neutral - 71 4251 SO_-1846G00584G00584 Neutral - 71 4386 SO_-1275G01259G01259 Neutral - 71 4430 SO_-501G01459G01459 Neutral - 71 4595 SO_-2700G02436G02436 Neutral - 71 4620 SO_-1275G02618G02618 Neutral - 71 5733 37_P12.1219979130358 Neutral - 37 5143 SO_-501G05623G05623 Neutral - 71 5144 SO_-501G05624G05624 Neutral - 71 5146 SO_-501G05626G05626 Neutral - 71 5496 7_-5842ILP0412113E041266 Neutral - 7
3165A>T	c.3165A>T	15		p.Ile1055Ile		Neutral	unvalidated	00/00/00	6
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5780 37_P13.4024735149135 Neutral - 37 2146 4_36957---36957 Neutral - 4 2747 19_11431---11431.001 Neutral - 19 2748 19_11431---11431.001 Neutral - 19 2749 19_17769---17769.001 Neutral - 19 3103 33_PSL2697---09-1304 Neutral - 33
3386T>C	c.3386T>C	15		p.Leu1129Ser		Neutral	unvalidated	00/00/00	6
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2356 4_23088---23088 Neutral - 4 2982 19_17587---17587.001 Neutral - 19 2983 19_13981---13981.001 Neutral - 19 2984 19_15859---15859.001 Neutral - 19 2985 19_19668---19668.001 Neutral - 19 4197 SO_-920G00379G00379 Neutral - 71
3468_3470delAGA	c.3468_3470delAGA	15		p.Glu1157del	Beta-catenin binding domain 3	Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5829 19_1611116111-00116111-001 Neutral - 19 5830 19_2715727157-00127157-001 Neutral - 19
3920T>A	c.3920T>A	15		p.Ile1307Lys		Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3099 33_PSL3028---10-331 Neutral - 33 4739 SO_-3195G03415G03415 Neutral - 71
3949G>C	c.3949G>C	15		p.Glu1317Gln		Neutral	unvalidated	00/00/00	5
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5761 2_02-ACT2008_14897_14897 Neutral - 2 2750 19_21943---21943-001 Neutral - 19 2751 19_19912---19112.001 Neutral - 19 3084 20_1713-04---5929 Neutral - 20 5251 SO_-4457G06580G06580 Neutral - 71
4326T>A	c.4326T>A	15		p.Pro1442Pro		Neutral	unvalidated	00/00/00	7
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2763 19_19206---19206.001 Neutral - 19 2764 19_21016---21016.001 Neutral - 19 2765 19_20067---20067-001 Neutral - 19 2766 19_24158---24158-001 Neutral - 19 2767 19_11268---11268.001 Neutral - 19 2768 19_19206---19206.001 Neutral - 19 2769 19_19206---19206.002 Neutral - 19
4345A>G	c.4345A>G	15		p.Lys1449Glu		Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3394 37_P09.3613935103954,1040 Neutral - 37 3395 37_P09.36946086467/93358 Neutral - 37
5274T>A	c.5274T>A	15		p.Ser1758Ser		Neutral	unvalidated	00/00/00	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 2978 19_20852---20852.001 Neutral - 19 2979 19_20852---20852.001 Neutral - 19 2980 19_15859---15859.001 Neutral - 19
5465A>T	c.5465A>T	15		p.Asp1822Val		Neutral	unvalidated	00/00/00	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5831 19_2231922319-00122319-001 Neutral - 19 5832 19_2418824188-00124188-001 Neutral - 19 5833 19_2534825348-00125348-001 Neutral - 19
5880A>G	c.5880A>G	15		p.Pro1960Pro	Beta-catenin degradation domai	Neutral	unvalidated	00/00/00	1
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5858 --- Neutral - 171
7504G>A	c.7504G>A	15		p.Gly2502Ser	Microtubule binding domain (ba	Neutral	unvalidated	00/00/00	4
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5816 19_9798---9798.001 Neutral - 19 3271 37_P05.05-E3419--- Neutral - 37 3272 37_P08.076880--- Neutral - 37 3273 37_P03.08195819580 Neutral - 37
7621A>G	c.7621A>G	15		p.Ile2541Val	Microtubule binding domain (ba	Neutral	unvalidated	00/00/00	2
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 3414 37_P09.1813116100825 Neutral - 37 3415 37_P09.18919380210 Neutral - 37
7704A>G	c.7704A>G	15		p.Gly2568Gly	Microtubule binding domain (ba	Neutral	French MMR network	25/03/15	3
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5817 19_26776---26776-001 Neutral - 19 5818 19_1611116111-00116111-001 Neutral - 19 3090 20_0910-01---2845 Neutral - 20
7862C>G	c.7862C>G	15		p.Ser2621Cys		Neutral	unvalidated	00/00/00	10
UMD_id Sample ID Gender Biological significance Geographic origin Mutation type References 5526 7_-5974ILP0510959E050855 Neutral - 7 2406 4_25979---25979 Neutral - 4 2701 10_APC-071---831P Neutral - 10 3065 19_23741---23741-001 Neutral - 19 3066 19_19208---19208.001 Neutral - 19 3246 33_SAT0278---08-104 Neutral - 33 3247 33_PSL2551---09-854 Neutral - 33 3506 37_P98.1324828 Neutral - 37 3507 37_P06.034075--- Neutral - 37 3508 37_P98.17213--- Neutral - 37